InDesign CS5Adobe has built-in a handy shortcut into InDesign that allows you to hide all the layers in your document except the one you wish to focus on.

When you have a lot of layers in your document and want to work on the objects on one single layer more easily, activate the Layers panel and hold theOption key down while you click the little eye icon of the layer you want to work on. All other layers in the document will be turned off. When you’re done, simply Option click the same eye icon of the active layer again to make the remaining layers visible.